A study on relationship between hepatic histopathological changes and data of preoperative liver function tests in 151 patients with gallstone disease.

The relationship between histopathology of liver and preoperative liver functional data was studied in 151 cases with cholelithiasis to clarify how gallstones effect on the hepatic tissues. The results were as follows. 1. Histologically, 80 % of all the cases showed hepatic inflammation. 2. The group with cholecystolithiasis had the highest frequency of hepatic parenchymatous changes. 3. The data of liver functions in the group with cholecystolithiasis were found to be almost within normal limits. Conversely, hepatolithiasis group showed to be moderate to severe disorder. 4. Although both groups with stasis and cirrhosis had hepatic functional disorder, the former showed to be moderate to severe, the latter to be normal to mild, in the magnitude of liver functional disorder. As a conclusion, the grade of liver functional disorder in cholelithiasis patients depends upon that of biliary stasis.